Comments on "Principles of Competitive Binding Assays"
نویسندگان
چکیده
منابع مشابه
Principles of competitive binding assays (saturation analyses). II. Sequential saturation.
The principles of sequential saturation as a form of competitive binding assays are discussed in detail and differentiated from those of equilibrium techniques. The rationale of its applicability in practice and its potential to increase sensitivity under certain assay conditions are demonstrated with three binding systems involving digoxin, insulin, and folates. The advantages and disadvantage...
متن کاملComments on Competitive Responsiveness
M Science features many and diverse articles that analyze competitive responsiveness. Although recent Marketing Science editorials (e.g., Shugan 2002) suggest that competitive responsiveness is only a part of a comprehensive competitive marketing strategy, it remains a vital part. For that reason and many others, Marketing Science is particularly proud of this special issue edited by David J. R...
متن کاملThree Principles of Competitive Nonlinear Pricing
We make three contributions to the theory of contracting under asymmetric information. First , we establish a competitive analog to the revelation principle which we call the implementation principle. This principle provides a complete characterization of all incentive compatible, indirect contracting mechanisms in terms of contract catalogs (or menus), and allows us to conclude that in competi...
متن کاملA Novel CXCR4-Selective High-Affinity Fluorescent Probe and Its Application in Competitive Binding Assays
We recently developed a new, rapid, and specific bioassay system that employs a fluorescent probe fabricated from our discovered CXCR4-specific ligand DV1. This new probe sensitively and selectively blocks the binding of native and synthetic ligands to CXCR4 at nanomolar levels, with a capability comparable to that seen with a conventional CXCR4 antibody. This nonradioactive, direct, and CXCR4-...
متن کاملMagnetic levitation as a platform for competitive protein-ligand binding assays.
This paper describes a method based on magnetic levitation (MagLev) that is capable of indirectly measuring the binding of unlabeled ligands to unlabeled protein. We demonstrate this method by measuring the affinity of unlabeled bovine carbonic anhydrase (BCA) for a variety of ligands (most of which are benzene sulfonamide derivatives). This method utilizes porous gel beads that are functionali...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Clinical Chemistry
سال: 1974
ISSN: 0009-9147,1530-8561
DOI: 10.1093/clinchem/20.1.89